POINT OF VIEW AT THE PROBLEM OF ATRIAL FIBRILLATION IN OBESE PATIENTS

Atrial fibrillation (AF) has a negative impact not only on the quality of life of patients, but also leads to cardioembolic complications, which increases mortality and disability of the population. Currently, studies show that the presence of obesity has a significant impact on the occurrence and recurrence of AF. In recent years, studies have been carried out proving the negative effect of adipose tissue on the myocardium, which manifests itself in changes in the structure of the myocardium and its functional state. Adipose tissue is a secretory organ capable of producing biologically active substances-adipokines that affect the processes of cardiac remodeling and is capable of supporting the processes of chronic inflammation; the most significant inflammatory activity is observed in epicardial adipose tissue. A practicing physician needs knowledge of the mechanisms of development and features of the manifestation of AF in patients with obesity in order to improve patient management tactics taking into account the principles of personalized medicine.

Keywords:atrial fibrillation, obesity, leptin, adiponectin, resistin, paroxysms, epicardial adipose tissue