Paderina Diana Zakirovna (Researcher of the Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMC, Tomsk )
Ivanova Svetlana Alexandrovna (Doctor of Medical Sciences, Professor,
Head of the Laboratory of Molecular Genetics and Biochemistry,
deputy Research Director of the Mental Health Research Institute
Tomsk NIMC, Tomsk
)
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Hyperprolactinemia is a common side effect associated with the use of antipsychotic drugs in the treatment of schizophrenia. Currently, most neuroleptics used in clinical practice are able to increase the level of prolactin in the blood, but the most prolactogenic are first-generation antipsychotics, and some second-generation antipsychotics. Associations of single nucleotide markers of the DRD2, HTR3A and PRL genes with the development of hyperprolactinemia in patients with schizophrenia were studied depending on the profile of the therapy received. It was shown that polymorphic variants of the studied genes contribute to the formation of a pathological phenotype.
Keywords:pharmacogenetics, dopamine, serotonin, PRL, schizophrenia, antipsychotics, hyperprolactinemia
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Read the full article …
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Citation link:
Paderina D. Z., Ivanova S. A. PHARMACOGENETIC STUDY OF NEUROLEPTIC HYPERPROLACTINEMIA IN PATIENTS WITH SCHIZOPHRENIA DEPENDING ON THE PROFILE OF ANTIPSYCHOTIC THERAPY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№04/2. -С. 188-191 DOI 10.37882/2223-2966.2024.4-2.28 |
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