PREGNANCY AND HPV: CLINICAL CASES

Rossolko Dmitry S., Fedulova Anastasia S., Kamalova Mehriniso T., Khusainova Khilola A.

Human papillomavirus (HPV) is the causative agent of long-term persistent infection among groups of sexually transmitted infections. HPV is detected in almost 90% of cases in patients with verified cervical cancer, which is the fourth most deadly type of cancer in women and is currently the most common pathogen causing cancer in women. Moreover, HPV infection is associated with many other diseases, including skin and anogenital warts, as well as genital and upper gastrointestinal cancers. Oncogenic types of HPV (16,18) often act as a trigger in the initiation of malignant transformation of pathological processes. Given the continued high burden of HPV-associated cancers, understanding the carcinogenicity of HPV remains important to better understand, prevent, and treat cancers associated with the infection. Pregnant women are particularly susceptible to infections during pregnancy, and most of them are self-limiting, which can be cleared by their autoimmunity, while persistent infections are associated with precancerous lesions and cancer of the anogenital mucosa in women. In addition, HPV infection can also affect reproductive health and fertility.

Keywords:gestational complications, HPV, pregnancy, HPV, DNA virus