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Correction of endothelial dysfunction in patients with severe frostbite injures

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Ju. Shapkin, N. Stekol'nikov, P. Gamzatova, M. Mamedova,  (Saratov State Medical University)

Series "Natural & Technical Sciences" # 09  2017
The study assesses the severity of manifestations of dysfunctions at various times from the time of injury by determining the content of soluble vascular adhesion molecules sICAM-1, sVCAM-1, sE-selectin, sP-selectin. There is a significant increase in the plasma concentration of these markers from the time of frostbite and to the formation of demarcation and suppurative complications. The obtained data show the high effectiveness of the Antistax preparation in complex treatment of frostbites, allowing to improve both the clinical outcomes of damage and to correct the manifestations of endothelial dysfunction. The remaining endothelial dysfunction subsequently becomes the leading pathogenetic mechanism for the development of long-term complications of frostbite.

Keywords: frostbite, endothelial dysfunction, "Antistax", molecules of cell adhesion.


Read the Full Article in Russian …

Ju. Shapkin, N. Stekol'nikov, P. Gamzatova, M. Mamedova, Journal "Modern science: actual problems of theory and practice".



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