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Dynamics of indicators of leptin, C-reactive protein, interleukin 6 and tumor necrosis factor in the process of antihyperglycemic therapy in patients suffering from GERD in the background of type 2 diabetes and obesity

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E. Andreeva,  (Candidate of Medical Sciences, Associate Professor, Stavropol State Medical University, Stavropol)

Series "Natural & Technical Sciences" # 10  2017
Obesity is a chronic multifactorial heterogeneous disease, manifested by excessive formation of adipose tissue, progressing in natural course.
Most often in clinical practice, obesity is associated with diabetes and GERD.
Metabolic activity of adipose tissue consists in the production of biologically active substances (leptin) and an increase in serum concentration of proinflammatory cytokines, which contributes to additional indirect sensitization of the esophagus, leading to an increase in the duration and severity of pathological reflux.
It is interesting to study the properties of new hypoglycemic drugs that can not only positively influence the parameters of carbohydrate metabolism, but also contribute to reducing the body weight of patients with a decrease in the metabolic activity of visceral adipose tissue and indirectly improving the course of GERD.
The purpose of the study was to study the effect of exenatide on the dynamics of leptin, interlein 6, tumor necrosis factor (TNF) and C-reactive protein in GERD on the background of type 2 diabetes and obesity.
Materials and methods. All patients were divided into 2 main groups and the control group. The number of patients in each group was equal to 50, the groups are comparable in terms of gender-age characteristics.
The first main group of patients suffering from GERD, type 2 diabetes and obesity took metformin at a dose of 2000 mg per day. The second main group of patients suffering from GERD, type 2 diabetes and obesity took exenatide 5 mg * 2 times a day subcutaneously. The control group consisted of patients with GERD without concomitant pathology.
As a result of 6 months therapy, it was noted that a comparable hypoglycemic effect was observed in Groups 1 and 2, the maximum significant decrease in BMI, the DeMeester index, the leptin level and the serum concentration of proinflammatory mediators in Group 2, indicating the role of visceral Fatty tissue in the pathogenesis of GERD development.

Keywords: visceral-abdominal obesity, type 2 diabetes, GERD.


Read the Full Article in Russian …

E. Andreeva, Journal "Modern science: actual problems of theory and practice".



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