Cherniakov Artem Viktorovich (PHD, - State Educational Institution of Higher Professional Education of the Russian Scientific Research Medical University. Nikolay Ivanovich Pirogov Russian Ministry of Health)
Balandina Anna Nikolaevna (PHD, Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology. Dmitry Rogachev Russian Ministry of Health)
Vardanyan David Martinovich (professor’s assistent, State Educational Institution of Higher Professional Education of the Russian Scientific Research Medical University. Nikolay Ivanovich Pirogov Russian Ministry of Health)
Grigoriev Alexey Sergeevich (professor’s assistant, State Educational Institution of Higher Professional Education of the Russian Scientific Research Medical University. Nikolay Ivanovich Pirogov Russian Ministry of Health)
Stupin Viktor Aleksandrovich (professor, State Educational Institution of Higher Professional Education of the Russian Scientific Research Medical University. Nikolay Ivanovich Pirogov Russian Ministry of Health)
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A prospective observational study assessing the effectiveness of treatment of unfractionated (UFH) and low molecular (LMWH) heparins weight of 60 patients with thrombosis of the deep veins of the lower limbs. Using standard laboratory methods (APTT, anti-Xa activity, d-dimer) and Thrombodynamics. Thrombodynamics test evaluates the overall plasma hemostasis and is able to identify the state of hyper-, normo- and hypocoagulation. The study design was based on the time of blood sampling from the introduction of heparin.
Against the backdrop of ongoing heparin therapy showed a significant change in Vi and Vs Thrombodynamics test, Tlag changes were noted. According to the results of treatment of 60 patients with DVT revealed a negative correlation between the average force APTT, Vi and Vs during therapy with UFH and negative high correlation between some anti, Vi and Vs in the treatment of LMWH. Evaluation Vi and Vs hypocoagulation allows you to compare the effect of UFH and LMWH, which is not possible using routine tests of hemostasis evaluation. Thus, Thrombodynamics test indicators able to assess the degree of anticoagulation, developing on the background of heparin therapy, regardless of the used heparin.
Keywords:deep vein thrombosis, anticoagulation, coagulation tests, Thrombodynamics test.
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Citation link:
Cherniakov A. V., Balandina A. N., Vardanyan D. M., Grigoriev A. S., Stupin V. A. Recent methods of monitoring the effectiveness of heparin treatment in patients with deep vein thrombosis of the lower limbs in hospital // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2016. -№03. -С. 69-77 |
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