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Comparative analysis of the immune status of patients with bladder cancer In the pre- and postoperative period

Alyaev Yuri   (MD, professor, Corresponding member of the Academy of Medical Sciences, Director of Fronstain Clinic of Urology Sechenov First Moscow state medical university Deputy director of Science Research Institute of uronephrology and reproductive human health of Sechenov First Moscow state medical university Head of department of Urology of Sechenov First Moscow state medical univer-sity )

Grigoryan Vagarshak   (MD, Professor of the Department of Urology of Sechenov First Moscow state medical university)

Ataullakhanov Ravshan   (MD, Head of Department of the State Enterprise "Institute of Immunology of the Federal Department of Biomedical and Extreme Problems at the Ministry of Health of Russian Federation", Head of Laboratory of immunity activation of Institute of Immunology )

Shpot Evgeny   (Ph.D., Associate Professor of the Department of Urology of Sechenov First Moscow state medical university)

Soblirov Timur   (Department of Urology of Sechenov First Moscow state medical university "In-stitute of Immunology" FMBA Russia)

The results of the comparative analysis of patients with bladder cancer in pre- and postoperative period. It is found that reducing the degree of differentiation of cancer of the bladder to moderate the high increases the number of activated HLA-DR + CD8 + T cells, while reducing the triple perforin content in these cells. These changes indicate a lengthy immune response reflecting early relapse or nonradical surgery.

Keywords:bladder cancer, immune status, HLA-DR + CD8 + T cells, postoperative relapse, perforin

 

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Citation link:
Alyaev Y. , Grigoryan V. , Ataullakhanov R. , Shpot E. , Soblirov T. Comparative analysis of the immune status of patients with bladder cancer In the pre- and postoperative period // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№01. -С. 61-65
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