Gadzhieva Lailakhanym (Dagestan State Medical University (Makhachkala))
Ahmedov Jalalutdin (Dagestan State Medical University (Makhachkala))
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Recently, an important role in the pathogenesis of brucellosis infection and its complications is attributed to oxidative stress. Goal. Comparative evaluation of the antioxidant system (AOS) in patients with brucellosis with and without nephropathy. Material and methods. The study included 51 women with brucellosis of the kidneys and 129 sick women (15-50 years) with brucellosis without nephropathy. The control group included 30 healthy women. All women underwent general clinical examination, as well as AOS research. Results. It was established that in patients with various clinical forms of brucellosis there is a decrease in the buffer capacity of the thiadisulfide unit of the AOS, an increase in the level of malonic dialdehyde, which is a marker of oxidative stress, and glutathione peroxidase, a catalyst for the reduction of peroxide lipids, while patients with brucellosis nephropathy exhibit more pronounced changes, than in patients without renal involvement. Conclusions. In women with brucellosis, there is an increase in the intensity of lipid peroxidation, a decrease in the antioxidant activity of the blood and a violation of the functional state of the AOS, manifested by an increase in the blood levels of SS-groups, a decrease in SH-groups and a thiol disulfide coefficient, and an increase in the level of glutathione peroxidase. The revealed disorders are more pronounced in patients with brucellosis nephropathy.
Keywords:brucellosis, women, nephropathy, antioxidant system, lipid peroxidation.
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Citation link:
Gadzhieva L. , Ahmedov J. Antioxidant system in women with brucellosis kidney diseases // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2018. -№02. -С. 77-81 |
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