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Serotonin as the primary cause of pulmonary hypertension: from hypothesis to clinical practice

Mustafin Alvar Alfredovich  (Kazan state medical University)

Nigmatullina Razinа Ramazanovna  (Kazan state medical University)

Bilalova Diana Faridovna  (Kazan state medical University)

To study the role of dopamine and serotonin systems in the pathogenesis of pulmonary hypertension (PH) in children with congenital heart defects (CHD) defined the concentrations of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid in plasma and platelets using high-performance liquid chromatography (HPLC) in urine by enzyme immunoassay (EI), evaluated their relationship with the degree of PH. Observed the increase of concentrations of 5-PT and 5-hydroxyindoleacetic acid in plasma in patients with pulmonary hypertension. Defined the high degree of correlation between the concentration of 5-hydroxyindoleacetic acid in plasma and urine with the degree of PH. Concentration of 5-hydroxyindoleacetic acid in the urine in the postoperative period decreased in all patients with CHD and reached normal, comparable with the control group values, which makes it possible to consider a method of determining 5-hydroxyindoleacetic acid urine, as a method of assessing of the effectiveness of therapy with PH.

Keywords:serotonin, 5-hydroxyindoleacetic acid, congenital heart disease (CHD), pulmonary hypertension (pH).
 

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Citation link:
Mustafin A. A., Nigmatullina R. R., Bilalova D. F. Serotonin as the primary cause of pulmonary hypertension: from hypothesis to clinical practice // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2018. -№03. -С. 107-111
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