Evaluation of the cardiovascular system in women with hypertension, depending on the level of estradiol

Koriagina N. A., Zhelobov V. G., Avdeev A. V., Melekhova O. B., Prokhorov K. V.

Were examined 64 women, 39,34 ± 1,98 years, with arterial hypertension, who did not take antihypertensive therapy. Depending on the level of estradiol and follicle-stimulating hormone (FSH), the respondents were divided into groups (gr.). 1 gr. - 34 with hypertension having a physiological menstrual cycle and estrogen deficiency. In 2 gr. - 30 with hypertension having a physiological menstrual cycle and a normal level of estradiol and FSH. Gr. comparison - 20 healthy women. Carried out: duplex scanning of the common carotid artery (СCA) and transthoracic echocardiographic examination of the heart, with a focus on the diastolic filling of the left ventricle. We have revealed a decrease in the elasticity of the СCA wall and an increase in its stiffness in hypertension, more pronounced with decreasing estradiol. The diastolic function in patients with a normal menstrual cycle and hypertension irrespective of the level of hormones, there is dysfunction, which manifests itself both as a violation of active relaxation and increased stiffness of the left ventricular myocardium, with a greater degree of estrogen deficiency.

Keywords:артериальная гипертензия, эстрадиол, женщины