Modern aspects and treatment of psoriasis

Letova Valeria Evgenievna, Abdulkarimova Hava Arbiana, Shchukin Serafima Sergeevna

The review of the literature on the problem of studying the pathogenetic mechanisms of psoriasis and modern methods of treatment of this disease is presented. The pathogenesis is based on the hyperproliferation of epidermal cells, the disruption of keratinocyte differentiation, the formation of immune-dependent cytokines and mediators, which induce an inflammatory reaction in the dermis. One of the most active directions in the treatment of psoriasis is genetically engineered biological preparations (GIBP). GIBP directly block IL12/23 or TNF-α, inhibiting inflammation. However, the lack of these drugs is immunogenicity and, as a rule, parenteral administration, which reduces the patients' adherence to the treatment of psoriasis. Also considered is a new drug of the class of small molecules, a phosphodiesterase inhibitor 4 - aprimilast.

Keywords:psoriasis, cytokines, corticosteroids, cytostatics, phototherapy, genetically engineered biological preparations, infliximab, ustekinumab, secukinumab, aprimilast