Vitamin D in children and adolescents with bronchial asthma

Kulieva Balkyz Pakhvatdinovna, Vitebskaya Alisa Vitalyevna, Kolosova Natalya Georgyevna

Study objectives: to identify the prevalence of vitamin D deficiency in children in the spring season; to compare the status of vitamin D in children with and without bronchial asthma (BA); to assess the impact of obesity on level of 25-hydroxyvitamin D [25(OH)D] in bronchial asthma. Materials and methods: 37 children and teenagers took part in the study: 18 patients with BA, 19 BA. Blood draws were carried out at the end of the period of minimum exposure to insolation (April-May 2017), levels of 25(OH)D were measured, the immune-enzyme assay was used. Height and weight of patients were defined also. Results: Mean level of vitamin D was lower among patients with BA (34.5 ± 12.2 nmol/l) compared to patients without BA (37.5 ± 14.9 nmol/l) (р=0.257). The higher prevalence of insufficiency and deficiency of vitamin D was identified in those with BA (16/18 patients, 89%) compared to patients without BA (14/19 patients, 74%). Patients with BA and normal weight had 25(OH)D level 36.9±11.7 (15.0 – 55.0) nmol/l, and in the case of obesity or overweight 27.9±10.8 (10.0 – 42.5) nmol/l (p=0.26). Conclusion: The results of the study confirm the prevalence of deficiency and insufficient of vitamin D among children and adolescents in Russian Federation. The high prevalence of vitamin D deficiency among patients with BA, especially in combination with obesity, underlines the reasonability of future more representative research trials.

Keywords:vitamin D, asthma, obesity, children