Microcirculation dysfunction in patients with rheumatoid arthritis as a predictor of joint function disorder: opportunities for prevention with the help of pentoxifylline electrophoresis

Andrienko Alexey Vladimirovich, Kulishova Tamara Viktorovna, Denisova Elena Anatolyevna, Weizmann Inna Alexandrovna, Chechina Irina Nikolaevna

The article reflects the results of the study of microcirculation in patients with rheumatoid arthritis, which were evaluated by laser doppler flowmetry. Statistically significant differences of microcirculation parameters in this pathology were revealed in comparison with the group of healthy persons. The paper presents the results of the study of the effectiveness of treatment and rehabilitation of patients with rheumatoid arthritis at the outpatient stage with the inclusion of pentoxifylline electrophoresis on the area of the affected joints. 101 patients with rheumatoid arthritis were examined and treated. Based on the treatment method, all patients were divided into 2 groups: the comparison one (n=50), receiving standard basic drug therapy with methotrexate, and the intervention one (n=51), receiving pentoxifylline electrophoresis treatment in addition to traditional therapy. According to the results of the study, the higher efficiency of complex treatment of rheumatoid arthritis with the inclusion of courses of pentoxifylline electrophoresis was proved.

Keywords:rheumatoid arthritis, laser doppler flowmetry, joint function disorder, electrophoresis, pentoxifylline