Outcome of neoadjuvant intra-arterial chemotherapy and radical hysterectomy for treatment of locally advanced cervical cancer

Parsyan Sh., Manikhas G., Lisyanskaya A., Cham K.

This paper highlights the issues and problems of treatment of locally advanced cervical cancer. Long-term results of complex treatment of 156 patients with stage 2-4 cervical cancer with neoadjuvant intra-arterial chemotherapy followed by surgical treatment are presented. The possibility and purpose of intra-arterial chemotherapy as the first stage of the complex treatment of locally advanced cervical cancer have been studied. The indications of the use of neoadjuvant intra-arterial chemotherapy are substantiated and pathologies-clinical prognostic factors of the prognosis of treatment of patients with locally advanced cervical cancer are revealed.

Keywords:locally advanced cervical cancer, neoadjuvant intra-arterial chemotherapy, irinotecan (CPT-11), carboplatin