Eff ect of point mutations in the INK4A/ARF locus on ARF-mediated autophagy in tumor cells

Soloviev Alexander, Budina Anna, Anaschenkova Tatiana

The article presents data on the effect of tumor-derived point mutations in the INK4a/ARF locus on ARF-mediated autophagy in human tumor cells. In experiments on cells of an osteosarcoma is shown that a point mutations of the gene ARF, located in a plot of activation of autophagy, impair the ability of tumor suppressor ARF to induce autophagy in tumor cells.

Keywords:autophagy, tumor suppressor, ARF, point mutations.