Apoptosis in HPV-associated cervical pathologies: change of markers

Vinogradova Olga Pavlovna, Artemova Olga Igorevna

The current stage of development of medicine demonstrates the presence of pathological processes at the molecular level. In particular, the phenomenon of apoptosis, programmed cell death, is being actively studied. In order to determine the role of apoptosis in the etiology and pathogenesis of HPV-associated cervical pathologies, such as leukoplakia and grade 1 dysplasia, the state of cervix in women of childbearing age was investigated. The study showed that in HPV-positive patients with grade 1 dysplasia, an apoptosis-resistant phenotype develops.

Keywords:grade 1 dysplasia, grade 2 dysplasia, cervical leukoplakia, caspase 3, caspase 9, apoptosis-resistant phenotype, cell death, cervical cancer