Humoral immunity in patients with different variants of clinical course of calculous cholecystitis

Yashnov A., Konovalova O., Hanina Y., Yashnova N., Vdovina M., Burtseva M.

Gallstone disease is one of the most common diseases of the digestive system in the world. In recent years, there has been an increase in morbidity among the working population, which has a negative impact on social activity and quality of life. Great difficulties in early clinical diagnosis and timely use of preventive measures are caused by nonspecific clinical manifestations and hidden course of cholelithiasis. Acute cholecystitis, in turn, occupies an honorable place among the urgent problems of modern surgery. Due to the introduction of modern methods of ultrasound diagnosis, it was possible to provide early detection of acute calculous and acalculous cholecystitis. However, due to minimally invasive interventions, the number of postoperative complications and mortality decreased. It should be noted that one of the problems of emergency surgery has now become atypical for destructive cholecystitis. However, currently there are no criteria in the diagnosis of this pathology, which can reliably determine the degree of destruction in the gallbladder. The aim of our work was to determine the state of humoral immunity (prospective study of immunogram) in patients suffering from different variants of the clinical course of calculous cholecystitis. A promising study of the immunogram of patients suffering from different variants of the clinical course of calculous cholecystitis. All patients are divided into 2 main groups: patients with chronic calculous cholecystitis and patients with acute calculous cholecystitis. In all examined groups of patients there is an increase in the level of total immunoglobulin. The most significant increase in the level of IgA, IgM is determined in patients with acute cholecystitis clinic.

Keywords:gallstone disease, immunoglobulins, acute cholecystitis, cholecystectomy, immunogram