The role of endothelial factors in the regulation of vascular tone in patients with resistant hypertension

Babakova E. K., Bagmet A. D., Zaitseva N. S., Egorov V. N., Taytina T.V. T. V.

Objective: to determine the amount of endothelin (1-21) in human serum in the presence of resistant hypertension. Materials and methods: the method of enzyme immunoassay was used to assess arterial stiffness. Conclusion: in the study group of patients with the presence of resistant hypertension, a significantly significant increase in the concentration of endothelin in blood plasma was found on average by 3.75 m/s (p<0.05). This indicates the presence of pronounced structural and functional changes in the vascular wall.

Keywords:endothelin, peptide, arterial stiffness, resistant hypertension, diabetes mellitus, dyscirculatory encephalopathy