Invasive assessment of central aortic blood pressure, differential effect of beta-blockers versus non-beta-blockers and their correlation with the severity of coronary heart disease in hypertensive patients

Koshimbaeva Leila Akynovna

Different classes of antihypertensive agents have different effects on Central blood pressure. Central systolic and pulse pressure cannot be accurately inferred from brachial blood pressure. Thus, there is potential for treating or overtreating hypertension based on shoulder blood pressure readings. Demographic and clinical indicators were comparable between patients in different groups of antihypertensive therapy. The mean systolic blood pressure difference (SBP) and mean pulse pressure (PP) ratios between the beta-blocker and non-beta-blocker groups were significantly different (p<0.0001) and (p=<0.0001), respectively. The mean Central SBP difference and the mean pressure ratio between the beta blocker and the beta blocker combination groups differed significantly, (P <0.0001 and p=0.0005, respectively). The mean SBP difference and mean PP ratio also differed significantly for beta-blocker monotherapy compared to non-beta-blocker drugs individually. In each group of antihypertensive therapy, the middle and severe groups of coronary heart disease had significantly higher levels of Central PP.

Keywords:Central aortic blood pressure, beta blockers, coronary heart disease