Insulin resistance in patients with pathological hyperprolaction

Agayan Arevik Andranikovna, Korneeva Elena V.

The aim of the study was to study changes in carbohydrate metabolism in patients with pathological hyperprolactinemia during treatment with dopamine agonists. We examined 86 patients with the syndrome of pathological hyperprolactinemia at the age of 34.2 ± 2.7 years. It was revealed that 59.3% of patients are overweight and obese. Against the background of the treatment of hyperprolactinemia with dopamine agonists, within 12 months, the level of prolactin returned to normal in 72% of patients. There was a decrease in fasting glucose by 16.9% among women and 33.3% among men and 2 hours after exercise - by 34% in women and 22.5% in men from baseline values. The mean serum initial and reactive insulin levels in patients with hyperprolactinemia and obesity were 2.5 times higher than reference values. During follow-up in patients of clinical groups, the level of reactive insulin was significantly reduced by 71% among women and men. The decrease in body weight among patients during treatment was positively correlated with a decrease in the HOMA-IR index.

Keywords:hyperprolactinemia, obesity, insulin resistance, dopamine agonists