Gluconeogenesis. Biological significance at pathological conditions

Krasnova Maria Gennadievna

Gluconeogenesis is a complex of metabolic processes aimed at maintaining normal glucose levels during intense exercise or starvation. The regulation of gluconeogenesis depends on the amount of substrate, redox status, hormone concentration and transcription of genes encoding gluconeogenic enzymes. Unregulated gluconeogenesis is an important factor in the pathogenesis of stress hyperglycemia. The last one is the most important problem of emergency medicine.

Keywords:Gluconeogenesis, regulation, pathological condition, enzymes of gluneogenesis, stress hyperglycemia.