Hemodynamic parameters depending on the level of pulse blood pressure in elderly and senile patients with combined cardiovascular disease

Denisova Elena Anatolyevna, Andrienko Alexey Vladimirovich, Veitsman Inna Alexandrovna

The role of different blood pressure levels in predicting adverse cardiovascular events has been radically revised, which was largely facilitated by the results of several studies that demonstrated that pulse blood pressure (PAD) may be a stronger predictor of cardiovascular risk than diastolic or systolic in the elderly. These data, as well as the results of a number of other studies, served as the basis for the leading role of a predictor of cardiovascular risk in patients with hypertension to be assigned to PAD. The level of PAD can also serve as an adequate marker of target organ damage in hypertension. In hypertensive patients, hypertension in combination with coronary artery disease and CHF in elderly was the remodeling of arteries of elastic type, which was characterized by increased stiffness and thickening of the arterial wall in the background dilatation of the blood vessel. As a result of degenerative changes in the vascular wall associated with special conditions of blood supply, constant deformation of the wall under the action of a pulse wave, elastin is damaged and destroyed and replaced with collagen. An increase in the stiffness (decrease in elasticity) of the vascular wall leads to a violation of the damping function of the aorta, the energy of the systole does not switch properly to the diastole, so the DAP is reduced, and the PAD increases. PAD is a complex value that reflects the function of the left ventricle of the heart, the elastic properties of the main vessels, and is an important parameter of hemodynamics.

Keywords:cardiovascular diseases, old age, hemodynamic parameters, arterial stiffness, pulse blood pressure.