Physiological reaction of micro-rheological properties of rat erythrocytes on aging of the organism

Grishan Margarita Alekseevna, Kotova Tatyana Vladimirovna

The study included 96 healthy outbred male rats, including 34 animals aged 18 months, 30 animals aged 24 months. and 32 heads at the age of 30 months. The control group consisted of 31 healthy outbred male rats at six months of age. In aging rats, an increase in the activity level of free radical oxidation processes in plasma lipids and red blood cells was found. With an increase in the chronological age in the blood of the observed rats, a decrease in the level of red blood cells-discocytes was noted, which was most pronounced in rats at 30 months of age. This was accompanied by an increase in their level of changed reversibly and irreversibly erythrocyte forms and an increase in spontaneous aggregation of red blood cells.

Keywords:rats, aging, red blood cells, cytoarchitecture, aggregation