The effect of advanced glycation end products on virus-associated ALI/ARDS in experimental diabetes mellitus and immunosuppression

Aleksandrov Andrei G., Savateeva-Lyubimova Tatiana N.

In this article we study the effect of advanced glycation end products on virus-associated acute lung injury (ALI) in animals with associated premorbid pathology such us alloxan-induced diabetes mellitus (AISD) and methotrexate-induced immunosuppression (MIIS). The mouse-adapted pandemic influenza virus A/California/7/09MA (H1N1) pdm09 was used for modeling viral infection at a dose of LD50. The severity of ALI was assessed by the level of saturation index and morphological changes in lungs. Level of AGEs was measured in the supernatant of lung homogenates by fluorescence. AGEs showed significant role on virus-induced ALI associated with AISD, but not with MIIS. Obtained results may be relevant for developing new ways of relieving virus-associated ALI with associated premorbid pathology various pathogenesis.

Keywords:advanced glycation end products, acute lung damage, flu, diabetes mellitus, immunosuppression.