The effectiveness of correction of osteopenia with calcium and vitamin d in men with bronchial asthma

Ivchenkova A. F., Sadykov F. A., Mutalova E. G.

The purpose of the study: to evaluate the effectiveness of calcium and vitamin D preparations for prevention of reduction of bone mineral density (BMD) in men with bronchial asthma (BA) in combination with osteopenia. Results. Before treatment, no differences were found between the two groups besides the level of β-cross laps which was significantly higher in the second group (p=0.0035). After 1 year of treatment the level of bone resorption marker (β-cross laps) insignificantly decreased and the level of marker of bone formation (total P1NP) insignificantly increased mainly in the second group, while both groups were no longer statistically significantly different in the level of β-cross laps. In two groups were not observed changes in the level of calcium in the blood and no identified reduction in BMD. Conclusions. Taking calcium and vitamin D medications and recommendations for expansion calcium intake with food for 12 months are equally effective to prevent a decrease in BMD in men with osteopenia and ВА. However, the prescription of calcium and vitamin D in a daily dose equivalent to 1,000 mg of calcium and 800 IU of vitamin D3, leads to a greater decrease in the level of β-cross laps and therefore may be more effective for long-term prevention.

Keywords:bronchial asthma, osteopenia, calcium and vitamin D, bone mineral density, biochemical markers of bone turnover.