Activation of cholinergic system of soil nematode caenorhabditis elegans maupas by Allium sativum l. juice

Egorova A., Kolsanova R., Kalinnikova T.

In experiments with soil nematode C. elegans it was shown that Allium sativum juice is toxic for nematodes. The target of toxic action of A. sativum is C. elegans nervous system. A. sativum juice increased the sensitivity of C. elegans organism to negative action of levamisole, agonist of nicotinic acetylcholine receptors. A. sativum juice also increased the nematodes sensitivity to the rise in endogenic acetylcholine level by partial inhibition of acetylcholine esterase by aldicarb. The results of this work show that the mechanism of toxic action of A. sativum juice consists in activation of nematodes’ cholinergic system.

Keywords:Allium sativum, anthelmintic drugs, Caenorhabditis elegans, levamisole, nicotinic acetylcholine receptors.