Metabolic risk factors of precancer diseases and endometrial cancer

Ivanov Maksim Dmitrievich, Parsadanyan Ararat Mikichovich, Kasparova Anzhelika Eduardovna

To date, it has been established that metabolic syndrome is not only a significant risk factor for cardiovascular diseases, but also makes a significant contribution to the development and progression of hyperplastic processes and endometrial cancer. The purpose of this work is to study the role of the main components of the metabolic syndrome in the development of endometrial cancer and precancerous diseases of the female reproductive sphere. The analysis of literary sources on the basis of scientific electronic libraries eLIBRARY, PubMed, Cyberlenink. In women with metabolic syndrome, the incidence of endometrial cancer increases by about 2 times, which is associated with metabolic and hormonal changes, such as insulin resistance, hyperinsulinemia, hyperestrogenia, a decrease in adiponectin and an increase in the concentration of leptin, which contribute to the development of pathological processes in the endometrium. Among the components of the metabolic syndrome, abdominal obesity, which contributes to the formation of chronic systemic inflammation, which is a favorable environment for malignant transformation of cells, has the greatest connection with the development of hyperplastic processes and endometrial cancer. However, a combination of disorders of carbohydrate metabolism, dyslipidemia and hypertension, regardless of the presence of obesity, also increases the risk of endometrial cancer. An integrated multidisciplinary approach to the management of women with metabolic syndrome and impaired reproductive sphere will allow timely identification and correction of existing risk factors for hyperplastic processes and endometrial cancer. It is advisable to include recommendations for reducing body weight in the program for the prevention of endometrial cancer and precancerous diseases of the reproductive female sphere in obese women.

Keywords:metabolic syndrome, endometrial hyperplastic processes, endometrial cancer, female gender, obesity