Omentin as an objective indicator of the probability of impaired carbohydrate and lipid metabolism in obese pregnant women in the first trimester of gestation

Datsenko N. S., Yakimova A. V.

Many researchers around the world report an alarming increase in the prevalence of obesity among all age groups, including women of reproductive age. The idea of the function of adipose tissue as just a fat depot has changed in recent years. Currently, the main focus is on the metabolic functions of adipose tissue, which are modulated by adipocytokines. Adipocytokines have been found to control insulin sensitivity, inflammatory activity, neuroendocrine activity, food and water consumption, reproduction, and bone metabolism. Omentin-1 is an adipocytokine with anti-inflammatory activity that is associated with various metabolic disorders. The aim of our study is to study the serum profiles of omentin-1, the relationship between levels of omentin-1 and insulin resistance during pregnancy in women with varying degrees of obesity in comparison with pregnant women with normal BMI. Our study showed that obese pregnant women had significantly lower serum concentrations of omentin-1 compared to the control group. Serum concentrations of omentin-1 are significantly lower in patients with grade III obesity compared to patients suffering from the first and second degrees of obesity. Accordingly, we can conclude that the concentration of serum omentin-1 is associated with the presence and severity of obesity in pregnant women. In addition, the article shows the relationship of serum omentin-1 with the concentration of TG, cholesterol, immunoreactive insulin and glycosylated hemoglobin in the blood of patients.

Keywords:pregnancy, omentin-1, obesity, insulin resistance, glycated hemoglobin.