Estimation of the prognostic value of ferritin in covid-conditioned lung lesions

Kudryashova Zlata Vladimirovna, Kobelevskaya Natalia Victorovna

Increases in serum ferritin levels in COVID-19 have been studied since the start of the pandemic, although the number of studies looking at the role of hyperferritinemia in COVID-19 continues to be significantly smaller than studies of other markers of inflammation. An increase in ferritin levels is mainly considered as a diagnostic criterion for the cytokine curtain, as well as a tool for assessing the severity of the course of the disease and predicting death in COVID-19. The aim of this study was to study the predictive value of serum ferritin levels and the dynamics of its indicators in patients with confirmed COVID-19 and acute interstitial pneumonia corresponding to CT 1 and CT 2 stages, and with the progression of lung lesions to CT 3 and CT 4. The study included 127 patients aged 42 to 83 years. An analysis of serum ferritin parameters and a comparison of the dynamics of ferritin levels between different groups of patients were carried out: without progression of viral lung damage and with its progression. The results showed that ferritin levels can be used for prognostic purposes, because it can predict the risk of lung disease progression. However, the prognostic value of an isolated determination of ferritin is limited only by stage CT 1. At stages CT 2 - CT 3, a high level of ferritin is associated with the already completed progression of viral lung damage, although it correlates with its severity, but is not prognostic.

Keywords:COVID-19, ferritin, acute interstitial pneumonia