Persistent plasticity of microorganisms as a strategy of their survival in the human body

Bugero Nina Vladimirovna, Ilyina Natalia Anatolyevna

This paper presents the results of a study that register high rates of invasion by data of the simplest foundry workers, characterized by hazardous working conditions of both physical and chemical nature. The article presents the characteristics of the persistent potential of the protozoan Blastocystis spp. Inhabiting the human intestine. The complex of persistence factors (ALA, ALFA and AGA) of the protozoa Blastocystis spp. Was studied. A direct correlation was found between the persistent activity of blastocysts and the depth of disturbances in the intestinal microbiocenosis. The effect of destabilizing factors of production has been established, which lead to the restructuring of the intestinal biome, contribute to a decrease in the indigenous group of microorganisms and an increase in conditionally pathogenic flora. These materials make it possible to use the most important biological properties of the survival of microorganisms to study the mechanisms of formation of microsymbiocenoses in the biotope of the large intestine and are a theoretical prerequisite for the development of a method for screening diagnostics of intestinal dysbiosis based on the determination of ALA, ALpha and AGA of clinical blastocyst isolates.

Keywords:microbiocenosis, parasitocenosis, dysbiotic disorders, antilysozyme, antilactoferrin, antihistone activity, Blastocystis spp.