The manifestation of delayed hypersensitivity in the purulent-inflammatory process of Candida-bacterial etiology under conditions of immunosuppression

Shatalova E. V., Parahina O. V., Khmelevskoy V. I.

In the development of any issues of purulent-septic processes of mixed etiology, the study of the structure of pathogens of nosocomial infections in the medical institutions of the region is of primary and fundamental importance. Studies have shown a significant increase (P<0.01) in the frequency of occurrence of fungi of the genus Candida spp., as the causative agent of HSP, in associations with various representatives of the domain of prokaryotic cells relative to monocultures (24.2% and 3.7%, respectively). It was found that the manifestation of delayed-type hypersensitivity in Candida-bacterial infection is directly dependent on the affiliation of the associated bacteria to the genus and species and is in a strong direct correlation (r = 0.987 + 0.090) with the dynamics of the clinical course of the burn wound, which is an indicator of the long-term persistence of pathogens of these symbioses in the body of immunosuppressed patients.

Keywords:mixed infections, immunosuppression, delayed-type hypersensitivity.