The application of regenerative cells of adequate tissue in canned treatment of vulva scleroatrophic licena

Arkhipova Valeria Ilinichna, Astrelina Tatyana Alekseevna, Kobzeva Irina Vladimirovna, Samoilov Alexander Sergeevich

Purpose: to present the results of the use of autologous regenerative cells of the stromal-vascular fraction of adipose tissue (SVF) in the conservative treatment of lichen sclerosus of the vulva. Materials and methods: The use of the SVF of adipose tissue was carried out in 8 patients aged from 23 to 80 years old (average age was 65.5 ± 5.3 years) with a histologically verified diagnosis of vulvar lichen sclerosus during conservative therapy. Results: The patients underwent intradermal injection of viable regenerative cells of the SVF of adipose tissue over the entire surface of the affected area in the labia majora and labia minora (foci of atrophy of the perineal mucosa) in a volume of 2 ml with an average cell count of 65 ± 25.7x106 / ml. After 1 month of observation, the patients clinically showed a decrease in itching and an improvement in the psycho-emotional state, and after 3 months, a physical examination revealed an improvement in tropism and pigmentation of damaged tissues (skin and mucous membranes of the perineum). After 6 months, histological examination of the vulvar mucosa in the biopsy specimen revealed intact stratified squamous keratinizing epithelium without signs of atypical. Conclusion: As a result of treatment of the SVF of adipose tissue, patients were created favorable conditions for the activation of immune, reparative processes, restoration of tropism and pigmentation of damaged tissues (skin and mucous membranes of the perineum), remodeling of fibrous and connective tissue, achieving a satisfactory cosmetic and functional result, reducing itching, improving psycho-emotional condition worthy of the quality of life.

Keywords:autologous, stromal-vascular fraction of adipose tissue, cellular therapy, lichen sclerosus of the vulva