Diagnostic aspects of the level of growth factors (PDGF-BB, EPO and HGF) in colon cancer

Volkov Stepan, Lobanov Sergey, Yashnov Alexey, Konovalova Olga

The article presents the results of a study of the level of growth factors in the blood serum of patients with cancer of the left half of the colon. On average, in cancer patients the level of such comparable substances as EGF, HGF, M-CSF, PDGF-AA, PDGF-BB was several times higher than in the control group (p <0.05). It was also found that at the age of over 50, the level of Angio protein-2, G-CSF, EPO, M-CSF, PDGF-AA, PDGF-BB, VEGF is higher than at the age of up to 50 (p <0.05 ). The revealed patterns made it possible to create an additive model for the formation of possible risk groups for the development of colon cancer. It was confirmed that the assessment of the level of HGF, EPO, PDGF-BB in blood plasma, in combination with age data, is an additional criterion in the early diagnosis of colon cancer.

Keywords:colon cancer, growth factors, diagnostic markers, test systems, blood tests.