Role of antioxidant enzyms in expired air condensate in chronic pulmonary disease in patients of Vladimir region

Saed Manas, Zaprudnova Elena Alexandrovna, Smirnov Mikhail Vladimirovich

One of the global problems in modern healthcare is the spread of chronic obstructive pulmonary disease (COPD), so there is a need to study the mechanism of its development and develop new methods of its treatment. The work is devoted to the study of the role of antioxidant enzymes in protection against free radical oxidation accompanying stress conditions occurring against the background of chronic disease. In the course of the work, the level of free radical parameters in the exhaled air condensate (CVC) was determined in patients with COPD during an exacerbation of the disease and after treatment, the activity of catalase and superoxide dismutase in CVC was determined in healthy people and in patients with COPD. The results obtained made it possible to assess the state of the oxidant - antioxidant system in patients with COPD in the Vladimir region. In the complex of examining these patients, it is recommended to investigate the condensate of exhaled air using an informative diagnostic method.

Keywords:antioxidant enzymes, free radical oxidation, catalases, oxidative stress, superoxide dismutase (SOD), COPD, exhaled air condensate (EBC).