Modeling of abdominal adhesiogenesis and its prevention in an experiment

Magomedov Muhuma Magomedovich, Magomedov Magomed Arsenevich, Magomedov Magomed Abdulhakovich

Meshes implanted intraperitoneally are known to cause adhesions, potentially leading to complications such as chronic pain, intestinal fistulas, infection, and adhesions. To model intestinal adhesions, a polyprolene mesh was used and its role in the development of adhesions was evaluated. This study introduces a model for investigating intestinal adhesions to the mesh and assesses whether visceral peritoneal damage is causal to the development of adhesions. Experimental modeling of postoperative intraabdominal adhesions using a polyproline mesh. Experiments were performed on 24 healthy dogs weighing 10-15 kg. At the first stage, the adhesive process was modeled using a 4 x 4 cm polyproline mesh fixed on the visceral surface of the cecum and deserization of the parietal peritoneum of the right mesogastric region. At the second stage, 14 days later, a relaparatomy and revision of the abdominal organs were performed with an assessment of the adhesive process. With the development of the adhesive process, the adhesions were dissected and removed from the visceral surface of the mesh. Further, randomization was performed with the division of experimental dogs into 4 groups using an amneotic membrane, 5-fluorouracil and mesogel. The fourth control group with intraperitoneal administration of 5% glucose. In an experiment on the model, it was found that the main condition for the formation of adhesion is damage to the mesothelium of the serous cover of the intestine by a mesh. The results of caecum adhesion to the mesh according to the result of Lauder C – 92%, and Hoffman N-90%. Histological examination showed adequate ingrowth of the mesh into the wall in all animals. The most promising results were obtained with the use of an amniotic membrane implant and 5 – fluorouracil, while the worst results were obtained with the use of mesogel. There were also statistically significant differences between the groups after histopathological examination.

Keywords:intraperitoneal adhesions, polypropylene mesh, adhesion formation, experimental study, caecum.