Sodium-glucose cotransporter inhibitors can positive affect the state of the brain

Kolesnikov O. L., Kolesnikova A. A., Tarabrina Iu. O.

Sodium-glucose co-transporter inhibitors can reduce the severity of adverse changes occurring in cerebral ischemia. Drugs of this group attenuated cognitive impairment arising from diabetes mellitus. The neuroprotective effect of sodium-glucose transporter inhibitors has been demonstrated in models of Alzheimer's and Parkinson's diseases. Canagliflozin improved memory status with scopolamine administration. Possible mechanisms of neuroprotective effects are discussed.

Keywords:sodium-glucose cotransporter, inhibitor, brain, ischemia, cognitive impairment