Method for treatment of mechanical jarcus with negative aeroions

Boyarkin E. V., Belyaev A. N., Bespalov N. N., Parkin P. N., Babas' D. V., Majorov A. V.

Objective: to develop a technology for the treatment of mechanical jaundice with negative aeroions. Materials and methods: 20 laboratory animals (mature male rats of the Vinar series with an average body weight of 200-250 g) were used in the experiment, divided into 2 groups: experimental – 15 and control – 5 individuals, respectively. Surgical treatment for the creation of reversible mechanical jaundice was performed under thiopental-sodium anesthesia. A day after the operation, the experimental group of animals was exposed to the general effect of negative aeroions for 30 calendar days of observation. Decompression of choledochus (resolution of mechanical jaundice) was performed on the 3rd day after surgery. During the experiment, the general condition of the animals was evaluated daily (behavior, reflexes, skin color, the condition of the postoperative wound), in order to control functional disorders of the liver, venous blood was taken from the tail vein for biochemical analysis (total bilirubin, alanine aminotransferase (AlAT), alkaline phosphatase (ALP), catalase). The deficit in the volume of circulating blood was compensated by bolus injection of an isotonic sodium chloride solution in an average dosage of 0.1 ml/kg of animal body weight into the tail vein. Results: positive results of the use of mechanical jaundice therapy with negative aeroions were obtained. Conclusion: negative aeroionotherapy provides antioxidant protection of hepatocytes in cytolytic syndrome caused by mechanical obstruction of the biliary system, accelerates the regeneration of tissues of postoperative wounds.

Keywords:obstruction of the biliary system, negative aeroion therapy, lipid peroxidation.