Features of local immunity in pregnant women with a new coronavirus infection COVID‑19

Sakhautdinova Indira Venerovna, Khaibullina Alfiya Rashitovna, Tayupova Irina Maratovna, Zasyadkin Igor Sergeevich

Coronavirus infection (COVID-19) is an acute viral disease caused by a new strain of RNA—genomic coronavirus SARS-CoV-2 with predominant upper respiratory tract damage. The infection, established by the UN in February 2020, remains relevant and spreading at lightning speed to this day. COVID-19 covered all continents in a matter of weeks and received the status of a particularly dangerous pandemic due to its contagiousness to humans. Coronavirus infection remains a polyethological disease with multisystem organ damage, which is based on hypoxia, vascular endothelial dysfunction, coagulopathy, hyperactivation of the immune response, as well as thrombosis. The particular interest of the COVID-19 pathogenesis in this work is focused on the local (local) immuno-inflammatory process, namely, the increase in pro- and anti-inflammatory mediators-cytokines in pregnant women infected with a new coronavirus infection. Due to the high risk of complications during pregnancy with COVID-19, the risk of maternal and perinatal mortality increases, making diagnosis and monitoring of pregnant women in the hospital a necessity. [6-8].

Keywords:interleukins, immunoglobulins, cytokines, coronavirus infection, pregnancy.