The effect of the levels of glycation end products on pregnancy outcomes, features of the course of the postpartum period, the condition of newborns in women with GSD

Tselkovich Lyudmila, Balter Regina, Ivanova Tatiana, Ibragimova Alina, Ryabov Alexey

A comparative analysis of the outcomes of pregnancy and childbirth in women with gestational diabetes mellitus (GSD), depending on the content of glycation end-product receptors (sRAGE), was carried out. The data of 214 maternity hospitals with alimentary and moderate obesity were analyzed. It has been established that the frequency of operative delivery is quite high in women with GSD. The proportion of children with hypoxia, disorders of carbohydrate and electrolyte metabolism is also high. Laboratory data confirmed the conclusion that, regardless of the level of glycemia, insulin resistance and the therapy received, sRAGE levels in patients with GSD are higher than in healthy women. It was determined that the high content of sRAGE in patients with alimentary obesity is a fairly stable indicator indicating the development of gestational and perinatal complications, therefore, the algorithm for their prevention should be based on sRAGE indicators.

Keywords:receptors of glycation end products, preeclampsia, gestational diabetes mellitus, placental insufficiency, newborns, fetal macrosomia.