The role of family history and genetic predisposition in detection of coronary heart disease in young persons. Literature review

Mitina Ekaterina Vladimirovna, Kuznetsov Vladimir Ivanovich, Sturov Nikolay Vladimirovich, Vasiliev Petr Andreevich

Cardiovascular disease (CVD) is the leading cause of death worldwide, with coronary artery disease (CHD) being the most common. Therefore, it is so important not only to engage in the diagnosis and treatment of CVD and IHD, but also prevention, one of the stages of which should be the identification of young people who are in a high risk zone. Epidemiological and clinical studies show that family history, as an indicator of heritability, is an important risk factor for noncommunicable chronic diseases. To protect young people, it is necessary to collect a detailed family history in order to identify predictors of coronary artery disease in parents and close relatives, since control of an extended lipid level is not mandatory in them during the period of medical examination. In this regard, doctors may miss genetic disorders of lipid metabolism. Understanding the hereditary causes of coronary artery disease has the potential to significantly improve the prevention, prognosis and therapy of ischemic heart disease.

Keywords:cardiovascular disease, family history, genetic predisposition, coronary heart disease