Early markers of an unfavorable prognosis of patients with coronary artery disease, stable angina pectoris after stenting of coronary vessels

Markelova Elena Vladimirovna, Semenikhin Andrey Anatolyevich, Kosciusko Anna Valeryevna

Diseases of the circulatory system currently occupy a leading position in mortality in the developed countries of the world. Percutaneous coronary intervention (PCI) is a modern type of surgical intervention on a working heart, performed in the conditions of X-ray surgery, for the treatment of coronary artery disease. One of the main problems of modern endovascular surgery is restenosis, repeated narrowing of more than 50% in the area of the previously implanted stent, which can be regarded as an unfavorable outcome of surgical treatment. According to foreign and domestic sources, the incidence of restenosis inside the stent is 5-18.4%. The search and study of early markers of an unfavorable outcome in patients with coronary artery disease, stable angina after coronary artery stenting can improve their duration and quality of life, as well as reduce the economic costs of treatment of this category of patients.

Keywords:Cytokines, growth factors, MMP and their inhibitors, coronary heart disease, stable angina pectoris, PCI, restenosis.