Role of extracellular vesicles in hemostasis disturbance and in the development of atherotrombosis in cardiovascular diseases (literature review)

Lomova Irina Pavlovna

The review considers the data of recent scientific research devoted to the study of the role of extracellular vesicles (EVs), membrane nanoparticles released by cells during activation, in the occurrence and progression of cardiovascular diseases (CVD). The role of EVs in hemostasis disorders, in the development of atherosclerosis, in the growth and instability of an atherosclerotic plaque, and in atherothrombosis has been analyzed. It was found that EVs are early markers and predictors of the development of CVD, their use will open up new approaches in diagnosis, prognosis, monitoring the effectiveness of treatment, as well as new therapeutic agents. The use of native or bioengineered EVs may represent new drug delivery tools to combat inflammation, atherosclerosis, and atherothrombosis.

Keywords:extracellular vesicles, atherothrombosis, cardiovascular diseases, disease predictors and markers, nanoparticles in diagnostics and treatment