Gut microbiota in Alzheimer's disease

Kuliyeva Elvina Rustamovna, Gumenyuk Lesya Nikolaevna, Meshchryak Daria Yurievna, Ignatikova Ekaterina Evgenievna, Titukh Ekaterina Evgenievna

The aim of the study consists of considering the changes in the taxonomic composition of intestinal microbiota and to assess the nature of their’s relationship between representatives of some bacterial taxa and Alzheimer's disease. In recent years, a significant pool of scientific data has been accumulated on the relationship between the gut microbiota and brain functioning. In addition, significant quantitative and qualitative changes in the gut microbiome in Alzheimer's disease have been reported. According to the distinct tendency of increasing the prevalence of Alzheimer's disease, its association with functional disability and complete loss of social independence, as well as the lack of effective therapies, the search for pathophysiological mechanisms of the intestinal microbiota's influence on the development and progression of Alzheimer's disease becoming important for nowadays. The present review discusses current ideas about the peculiarities of changes in the gut microbiota in Alzheimer's disease and their relationship with its development and progression, which can become a justification for further research, and possibly opens up new approaches to the treatment of this disease.

Keywords:Alzheimer’s disease, dementia, gut microbiota, short-chain fatty acids, lipopolysaccharides, neurotransmitters.