Clinical and morphological risk factors for recurrence of stage I endometrial cancer

Tripac Irina Evghenii, Stratan Valentina Gheorghy, Tutuianu Valerii Grighory, Sitnic Victor Iury, Dobrovolskaia Aliona Victor, Misina Ana Evghenii

The increase in the incidence of endometrial cancer dictates the need not only for early detection of this disease, but also for proper treatment, taking into account clinical and pathological prognostic factors and patterns of recurrence. According to the current ESMO guidelines for the management of patients with endometrial tumors, treatment tactics are determined by the results of risk stratification. Cell proliferation is an indicator of the degree of tumor aggressiveness, which can be assessed using the percentage of Ki-67-positive nuclei. The expression of the Ki-67 antigen was determined by immunohistochemical method in endometrial tissue in 100 examined patients with stage I-II EC. The Ki-67 marker is a predictive risk factor for the recurrence of stage 1 endometrial cancer. The expression level of the Ki-67 marker depended on the degree of tumor differentiation and was a predictor of an unfavorable disease prognosis.

Keywords:endometrial cancer, atypical endometrial hyperplasia, disease prognosis, reccurences.