Kolesnikov O. L. (Doctor of Science in Medical Sciences, Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))
Kolesnikova A. A. (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))
Tarabrina Iu. O. (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))
Sineglazova A. V. (Doctor of Science in Medical Sciences, Associate Professor, FSBEI HE Kazan State Medical University MOH Russia (Kazan))
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Drugs from the group of dipeptidyl peptidase 4 inhibitors have an anti-inflammatory effect. It was recorded on models of atherosclerosis, lung and kidney damage, in cell cultures stimulated by lipopolysaccharide. There were decreased levels of proinflammatory cytokines, formation of the M2 macrophage phenotype, a decrease in the number of cells in the tissues, a decrease in edema as well as a decrease in the content of reactive oxygen species and nitric oxide.
Keywords:dipeptidyl peptidase 4 inhibitor, inflammation, macrophage, proinflammatory cytokines, lung, atherosclerosis.
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Citation link:
Kolesnikov O. L., Kolesnikova A. A., Tarabrina I. O., Sineglazova A. V. About anti-inflammatory effects of dipeptidyl peptidase 4 inhibitors // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№01/2. -С. 98-102 DOI 10.37882/2223-2966.2022.01-2.09 |
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