The effect of thioctic acid on the risk of cardiovascular events in patients with newly diagnosed type 2 diabetes mellitus after myocardial infarction

Yanovsky Konstantin Gennadievich

Diabetes mellitus is one of the most common chronic diseases in the world, has a significant negative impact on the course of cardiovascular pathology and myocardial infarction, in particular. Thioctic acid, due to its effects, can have a positive effect on the risks of developing undesirable cardiovascular events (CVS) in patients with newly diagnosed type 2 diabetes mellitus after a myocardial infarction. Aim. The aim of the work is to study the effect of thioctic acid on the risk of developing undesirable CFS in patients with newly diagnosed diabetes mellitus in combination with diabetic polyneuropathy who have suffered a myocardial infarction. Materials and methods. The object of the study was 60 people with newly diagnosed diabetes mellitus, with an established diagnosis of myocardial infarction. Patients underwent a set of standard hospital studies according to the protocols for the management of these diseases. Evaluation of undesirable CV was carried out using electrocardiography and echocardiography. On the 3rd day from hospitalization, groups of patients were identified who were additionally prescribed thioctic acid at a dosage of 600 mg / day orally for three months. After 3 and 12 months from the beginning of the study, repeated control studies were conducted. The data obtained were processed using IBM ® SPSS Statistics. The differences were recognized as statistically significant at p<0.05. Results. By the time of the intermediate control, a statistically significant decrease in the level of glycosylated hemoglobin was obtained to 7.2% [95% CI 6.58-7.7, p=0.001], which is 0.25% lower than the values of the control group (p=0.001), the level of triglycerides to 1.61 mmol/l [95% CI 0.99-2.23, p=0.0001], which is 1.21 mmol/l lower than the control group (p=0.003), the HDL index at the final stage was 0.2 mmol/l (p=0.001). There was a decrease in the level of background troponin T to the level of 1.45 ng/l (p=0.004), which is 4.6 ng/l lower than the control group (p=0.003). The control group demonstrated a statistically significant increase in the prevalence of non-lethal arrhythmias by 20% (p=0.013), whereas in the experimental group it was absent. Conclusions. Thioctic acid showed a significant effect on low-density lipoproteins, glycosylated hemoglobin and triglycerides. Thioctic acid reduces the risk of nonlethal arrhythmias in patients with newly diagnosed diabetes mellitus and myocardial infarction in a 12-month period.

Keywords:Diabetes mellitus, myocardial infarction, thioctic acid, non-lethal arrhythmias.