Optimization of the treatment program for acute coronary syndrome with the type 2-diabetes in the condition of hyperventilation: analysis of impact to outcomes

Voronin Nikita I., Kuznetsov Sergei I., Kuznetsov Dmitry S.

The article presents data from an original study on the implementation and empirical verification of the effectiveness of the developed therapeutic complex aimed at improving the intensive treatment of the nosological association « acute coronary syndrome (as the underlying disease) + type 2 diabetes mellitus (as a background pathology) + hyperventilation syndrome (as a concomitant state)». The author's therapeutic complex is based on a controlled change in auxiliary respiratory oxygenation «downward», provided that basic pharmacotherapy must be supplemented with a balanced combination of antihypoxic drugs and antiaggregant of new generation. A comparative study of two groups of thematic patients was carried out - using the developed complex and using the «traditional approach». The complex key parameters of the outcomes of the underlying disease in patients were studied using clinical assessment of functional classes of angina pectoris and veloergometric assessment of exercise tolerance. When using the developed therapeutic complex in comparison with the «traditional approach», a fundamental improvement in the outcomes of angina pectoris was established, which was confirmed by both the ratio of functional classes and the results of bicycle ergometry. The obtained data of intergroup differences have a high level of statistical significance. This proved the significant actual effectiveness of the developed therapeutic complex. The data presented in the article are distinguished by novelty and practical applicability, which makes it possible to recommend them for further implementation in the practice of the clinic of internal diseases.

Keywords:unstable angina pectoris, diabetes mellitus, hyperventilation syndrome, therapeutic complex, outcomes.