Clinical, pathological, gender, and demographic features of NSCLC patients with molecular genetic mutations in the Khanty-Mansiysk autonomous district-Yugra

Troyan Pavel Petrovich, Mordovskii Alexey Alexandrovich, Aksarin Alexey Alexandrovich, Parsadanyan Ararat Mikichovich

The aim of the study was to investigate clinical, pathological, gender and demographic features of NSCLC patients with molecular genetic changes and their frequency in the Khanty-Mansiysk autonomous district-Yugra. The clinical material for the study consisted of 482 NSCLC patients. Genetic mutations were observed more frequently in women than in men (55% vs. 45%); in lung adenocarcinoma (91,2%); among nonsmokers (57,5%); among the native population of the district-Yugra (81.2%). The share of EGFR gene mutations in the structure of all investigated NSCLC patients in the district was 10.4% (in lung adenocarcinoma - 14%), which is lower than in the Russian Federation - 18%. The analysis of gender, clinical, pathological and demographic differences in patients with gene mutations revealed a high frequency of EGFR gene mutations among women, nonsmokers and people living in Yugra for more than 30 years. Translocation of the ALK gene was statistically significantly more frequent in the younger subgroups of patients and those who had lived in the Khanty-Mansiysk autonomous district-Yugra for more than 20 years. The high frequency of KRAS gene mutation was statistically significantly more frequent among the smoking patients while ERBB2(HER2) gene amplification was mostly detected only in male smokers irrespective of the histological subtype. Knowledge of the molecular genetic palette of lung cancer in Yugra allows us to develop the right organizational measures for the drug treatment of NSCLC patients.

Keywords:lung cancer, morbidity, mortality, adenocarcinoma, squamous cell cancer, biomarkers, molecular genetic diagnosis, EGFR, ALK.