Prognostic value of the density index of the prostate-specific antigen in the algorithm for the diagnosis of prostate cancer

Mustafayev Ruslan Fikrat, Darvin Vladimir Vasilievich

The aim of the study was to determine the significance of the PSA density index for predicting prostate cancer. Materials and Methods: We examined 103 men aged 54 to 73 years who, during annual screening, showed for the first time an increase in the level of total PSA above 4 ng/ml. The patients underwent a transrectal ultrasound examination of the prostate gland with a puncture biopsy of the prostate and taking material for its pathomorphological examination. Determination of the PSA density index revealed that in patients with pathomorphological changes characteristic of prostate cancer, the level of the indicator was 0.26±0.5 ng/ml per cm3, which was 2.9 times higher than in patients without histological changes. changes – 0.09±0.3 ng/ml per cm3 (р≥0.05). The obtained data suggest that the PSA density index can be informative in assessing the risks of developing prostate cancer: with a pronounced prostate volume, but a slight increase in the level of total PSA, the PSA density index will be lower than 0.15 ng / ml per cm3 and the risk of developing prostate cancer will be low, while with a high level of total PSA and a relatively small prostate volume, the PSA density index increases along with the risk of developing an oncological process. The data obtained are the basis for further research in this direction.

Keywords:Prostate cancer, early diagnosis, prostate-specific antigen, PSA density index.