Vaccination against HPV as a fundamental mechanism for reducing papilloma virus induced cancer morbidity and mortality for the future generation under modern conditions

Chernobrovkina Alla Evgenievna, Ashrafyan Lev Andreevich, Bashketova Natalia Semyonovna

The brilliant German scientist Harold zur Hausen, being an obstetrician-gynecologist, microbiologist and immunologist, devoted his entire exploratory scientific life to the identification of diseases caused by various viruses. Throughout his professional life, the scientist worked to prove the hypothesis that cancers can be caused by viruses. Proving one after another the involvement of viruses, such as the DNA of the Epstein-Barr virus, adenoviruses, human papillomaviruses. Harold and his team isolated human papillomavirus type 16 (HPV-16) in 1983 and type 18 (HPV-18) in 1984. For his experiments with the search for viruses in cancer cells, Harold zur Hausen used the technique of in situ hybridization of viral DNA using a HeLa cervical tumor cell culture stored at Johns Hopkins University. HeLa cell culture - named after the first letters of the name and surname of a 31-year-old dark-skinned patient with many children, Henrietta Lacks, who died of cervical cancer and human papillomavirus type 16 was isolated from a culture of dividing cells obtained by biopsy. The viral DNA found by him in tumor cells, the expression of viral genes in tumor cells, as well as epidemiological data, made it possible to state with a high degree of probability that it is the virus that acts as an etiological factor in the development of a tumor.

Keywords:vaccination of children, human papillomavirus, cervical cancer, oncological diseases.